Monkeypox Outbreak 2022: Essentials for Clinicians

Monkeypox virus is an orthopoxvirus that causes a disease with symptoms similar, but less severe, to smallpox. While smallpox was eradicated in 1980, Monkeypox continues to occur in countries of central and west Africa. Two distinct clades are identified: the west African clade and the Congo Basin clade, also known as the central African clade. Monkeypox is a zoonosis: a disease that is transmitted from animals to humans. Cases are often found close to tropical rainforests where there are animals that carry the virus. Evidence of Monkeypox virus infection has been found in animals including squirrels, Gambian poached rats, dormice, different species of monkeys and others. Human-to-human transmission is limited. It can be transmitted through contact with bodily fluids, lesions on the skin or on internal mucosal surfaces, such as in the mouth or throat, respiratory droplets, and contaminated objects. The recent increased speed of infections in Europe and the United States, and the general inexperience of clinicians in these countries with Monkeypox viral infection, warrants educational interventions focusing on the transmission, clinical presentation, public health mitigation measures, course of illness, and treatment of Monkeypox viral infection.    

Target Audience

This activity is intended for physicians, nurses and advanced practice providers throughout Mass General Brigham

Learning Objectives

Upon completion of this activity, participants will be able to:

  1. Describe the various forms of transmission of Monkeypox viral infection and precautions healthcare providers need to take in the ambulatory and inpatient settings.
  2. Identify the duration of the incubation period and clinical signs of Monkeypox viral infection.
  3. Compare Monkeypox viral infection treatment, morbidity, and mortality to other related viral infectious diseases.

Additional Information

Provided by: 

Mass General Brigham

Course summary
Available credit: 
  • 0.50 AMA PRA Category 1 Credit™
  • 0.50 Participation
Course opens: 
Course expires: 

Michael Klompas, MD, MPH - Speaker
Infectious Disease Physician
Hospital Epidemiologist
Brigham and Women’s Hospital

Robert J. Birnbaum, MD, PhD - Moderator
Vice President, Continuing Professional  Development & Implementation Science
Director, Healthcare Knowledge Engineering & Translation Laboratory
Mass General Brigham

Disclosure Summary of Relevant Financial Relationships

Companies that are ineligible to be accredited in the ACCME System (ineligible companies) are those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. Examples of such organizations include:

  • Advertising, marketing, or communication firms whose clients are ineligible companies
  • Bio-medical startups that have begun a governmental regulatory approval process
  • Compounding pharmacies that manufacture proprietary compounds
  • Device manufacturers or distributors
  • Diagnostic labs that sell proprietary products
  • Growers, distributors, manufacturers or sellers of medical foods and dietary supplements
  • Manufacturers of health-related wearable products
  • Pharmaceutical companies or distributors
  • Pharmacy benefit managers
  • Reagent manufacturers or sellers

For more information:

Mass General Brigham has implemented a process to mitigate relevant financial relationships for this continuing education (CE) activity to help ensure content objectivity, independence, fair balance and ensure that the content is aligned with the interest of the public. 

The following planners have reported no relevant financial relationship with an ineligible company:

Robert J. Birnbaum, MD, PhD
R. Gino Chisari, RN, DNP
J. Kevin Tucker, MD

The following speakers have reported no relevant financial relationships with an ineligible company:

Robert J. Birnbaum, MD, PhD
Michael Klompas, MD, MPH

In support of improving patient care, Mass General Brigham is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Mass General Brigham designates this enduring activity for a maximum of 0.50 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 0.50 AMA PRA Category 1 Credit™
  • 0.50 Participation


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