Description

The presentation will focus on the epidemiology and risk factors impacting HIV-associated neurocognitive disorders (HAND) and other dementias in ART-treated individuals with HIV over age 50. It will also focus on current HIV clinical guidelines related to cognitive disorders, areas of active research to identify blood, cerebrospinal fluid and imaging biomarkers and define critical gaps in our understanding and treatment of cognitive disorders among an aging HIV population

Live broadcasts begin promply at 8 am EST.

Each live broadcast will be available as an on-demand archived version. 

Learning Objectives

Upon completion of this activity, participants will be able to:

1. Integrate screening tools into practice to identify the spectrum of HIV-Associated Neurocognitive Disorders.
2. Describe the interplay of psychiatric diagnoses including depression and substance use disorder in diagnosis of neurocognitive disease.
3. Utilize the CNS Penetration Effectiveness (CPE) score to optimize ART regimens in HIV CNS viral escape.

Target Audience

This activity is intended for HIV clinicians and caregivers, including physicians, nurse practitioners, and physicians' assistants.

Faculty

Shibani Mukerji, MD, PhD
Associate Director of the Neuroinfectious Diseases Unit
Massachusetts General Hospital

Dr. Shibani Mukerji is a board-certified neurologist and the Associate Director of the Neuroinfectious Diseases Unit at Massachusetts General Hospital. She is an M.D and Ph.D. graduate of Case Western Reserve School of Medicine, and holds a master's degree in translational science from Harvard School of Medicine. Dr. Mukerji received specialized clinical training in the neurological management of infectious diseases from the Partners (Massachusetts General Hospital/Brigham and Women's Hospital) residency and fellowship programs and sees patients living with HIV infection. Her research focuses on computational methods to integrate patient-derived data including clinical, laboratory, neuroimaging, and metabolite profiling to longitudinally model cognitive decline and persistent depressive symptoms in treated HIV-infected adults. She has additionally studied risk factors impacting HIV-1 RNA detection in cerebrospinal fluid among people with HIV infection. Dr. Mukerji is supported by funds from the National Institutes of Mental Health and Center for AIDS Research.

CME/CE Information

Accreditation

Partners HealthCare System is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Partners HealthCare System designates this live activity for a maximum 1 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity

FACULTY DISCLOSURE STATEMENTS 
In accord with the disclosure policy of Partners HealthCare System as well as guidelines of the Accreditation Council for Continuing Medical Education (ACCME), planners, speakers and anyone who may have an influence on the content of the activity have been asked to disclose any relationship they or their spouse/partner have to companies producing pharmaceuticals, medical equipment, devices, etc. that may be germane to the content of their presentation. Such disclosure is not intended to suggest or condone bias, but provides participants with information that might be of potential importance to their evaluation of a given presentation.

RESOLUTION OF CONFLICTS OF INTEREST (COI)
Partners HealthCare System has implemented a process to resolve potential COIs for this CME activity to help ensure content objectivity, independence, fair balance and ensure that the content is aligned with the interest of the public.

The following planner and/or their spouse/partner have reported no relevant financial relationship with a commercial interest:
Jacqueline Chu, MD
Virginia Triant, MD, MPH

The following planner and/or their spouse/partner have reported a relevant financial relationship with a commercial interest:
Rajesh T. Gandhi, MD
Grant Funding: Gilead, Merck, ViiV
Consultant: Theratechnologies; EMD Serono

The following speaker and/or their spouse/partner have reported no relevant financial relationships with a commercial interest:
Shibani Mukerji, MD, PhD

Hardware/Software Specifications: 

This internet-based CME activity is best experienced Microsoft Internet Explorer 9.0 or later, Mozilla Firefox 13 or later, Chrome 16 or later, Safari (version 5 or later)​​​​​​

This Web site requires that JavaScript and session cookies be enabled. Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Adobe Acrobat, and Microsoft PowerPoint.

Optimal System Configuration: 
Flash Player: Adobe Flash Player 10.1+
Browser: Firefox 13+, Internet Explorer 9.0+, Safari 13+, or Google Chrome 16+
Operating System: Windows Vista,7,8 or Mac OS X 10.4+
Internet Connection: 1 Mbps or higher

Minimum Requirements: 
Windows PC: 
Intel Pentium 4 or equivalent with 2.33 GHz processor; Windows XP; 512 MB RAM; Video Card at least 64MB of video memory; Sound Card at least 16-bit; Macromedia Flash Player 10 or higher, audio playback with speakers for programs with video content; Firefox 3+, Internet Explorer 7.0+, Safari 4+, Google Chrome, or Opera
Macintosh: 
Mac OS X 10.3 or higher with latest updates installed; 1.83MHz Intel Core Duo or faster; RAM: 128MB or more; Video Card: at least 128MB of video memory; Sound Card: at least 16-bit