Enteric alpha-synuclein membrane-binding predicts Parkinson’s disease pathology

Virginia Gao, M.D., Ph.D.
Instructor in Neurology and Neuroscience
Laboratory of Jacqueline Burré
Weill Cornell Medicine 
Department of Neurology

Zoom only: https://partners.zoom.us/j/88601852915
 

Learning objectives:
1) Under physiological conditions, alpha-synuclein is in equilibrium between a synaptic vesicle membrane-bound state and an unstructured cytosolic state
2) Alpha-synuclein membrane-binding is altered by disease-causing mutations and in the brain and gut in mouse models of PD
3) Changes in alpha-synuclein membrane-binding can be detected in PD colonic biopsies

Course Director: Gary Ho, MD, PhD & Richard Krolewski, MD, PhD

Coordinator: Barbara Kelly Changizi, MD ([email protected])

For questions regarding the registration process, please contact Mass General Brigham Office of Continuing Professional Development at [email protected].

You may print individual certificates throughout the year; your cumulative list of sessions attended is accessible on your transcript.

SYSTEMWIDE ACCESS

Participation instructions:

This session is open to all Mass General Brigham clinical staff

Meeting link: https://partners.zoom.us/j/6324421503

Please make sure your first name, last name and institution are visible when you sign in.
If you are not identifiable as a Mass General Brigham staff, you will not be allowed into the meeting:

This activity is intended for  with Physicians, researchers, affiliated health professions (NP, PA, physical therapists, social workers), residents, medical students with specialties of Neurology.

ACCREDITATION

In support of improving patient care, Mass General Brigham is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Credit Designation Statements

AMA PRA Category 1 Credit^TM
Mass General Brigham designates this live activity for a maximum of 1 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.