February 10, 2022 AI4C: Generalizable prediction of sudden cardiac death using ECG waveforms

February 10, 2022

Every year, 300-400,000 Americans suffer from sudden cardiac death. Some of these would be preventable with an implanted cardioverter defibrillator (ICD), which restore normal heart rhythm, but the vast majority of deaths lack known risk factors pre-mortem. We draw on a dataset of over 400,000 ECGs from a regional health system in Sweden, linked to death certificates, and train a residual neural network to predict sudden cardiac death. In an independent validation set of patients from the same region, we show that our model adds considerable predictive power, both in terms of standard metrics (AUC), and by identifying a large number of high-risk patients lacking traditional risk factors. To investigate whether predictable deaths are also preventable, we show that high-risk patients - and only high-risk patients - who receive a defibrillator have significantly lower mortality. Finally, we apply the model to a completely independent validation set of patients, drawn from the emergency department of the largest hospital in Taiwan, and show that it accurately discriminates patients who go on to suffer cardiac arrest from healthy controls.

Target Audience

This lecture series in intended for Physicians of all specialties, nurses, Physician Assistants, Information Technology Specialists, and Researchers interested in Artificial Intelligence in healthcare. Faculty of all levels, students, residents, and fellows welcome. Personnel from the healthcare technology sector may also be interested in attending the series.

Learning Objectives

Upon completion of this activity, participants will be able to:

  1. Describe Artificial Intelligence (AI) and Machine Learning (ML) at a high-level.
  2. Identify current limitations of AI in healthcare.
  3. Cite examples of AI as applied to imaging and other healthcare data.
  4. Describe example AI tools that can impact workflow in the healthcare arena.
  5. Utilize clinical AI applications appropriately.

Additional Information

Provided by: 

Massachusetts General Hospital and Brigham & Women's Hospital, Center for Clinical Data Science & Mass General Brigham


Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Participation
Course opens: 
Course expires: 
Event starts: 
02/10/2022 - 12:00pm EST
Event ends: 
02/10/2022 - 1:00pm EST
MGH & BWH Center for Clinical Data Science
Boston, MA
United States

Course Director

Katherine P. Andriole, PhD., FSIIM

Director of Research, Strategy and Operations
MGH & BWH Center for Clinical Data Science
Associate Professor of Radiology
Brigham and Women’s Hospital
Harvard Medical School
Boston, MA



Ziad Obermeyer, MD

Associate Professor
Blue Cross of California Distinguished Professor
University of California, Berkeley

In support of improving patient care, Mass General Brigham is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Mass General Brigham designates this live activity for a maximum of 1 AMA PRA Category 1 Credit™ per session. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 Participation


Please login or register to take this course.
Registration TypeTuition Fee
(per session if you are seeking credit)
MDs, DOs, NPs, & PAs$20
Other Health Care Professionals $10


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